منابع مشابه
Tunable leuko-polymersomes that adhere specifically to inflammatory markers.
The polymersome, a fully synthetic cell mimetic, is a tunable platform for drug delivery vehicles to detect and treat disease (theranostics). Here, we design a leuko-polymersome, a polymersome with the adhesive properties of leukocytes, which can effectively bind to inflammatory sites under flow. We hypothesize that optimal leukocyte adhesion can be recreated with ligands that mimic receptors o...
متن کاملPolymersomes.
Polymersomes are self-assembled polymer shells composed of block copolymer amphiphiles. These synthetic amphiphiles have amphiphilicity similar to lipids, but they have much larger molecular weights, so for this reason--along with others reviewed here--comparisons of polymersomes with viral capsids composed of large polypeptide chains are highly appropriate. We summarize the wide range of polym...
متن کاملClinical features of leuko-araiosis.
OBJECTIVE To study the clinical features of leuko-araiosis. METHODS Age matched groups of patients with a CT finding of pure leukoaraiosis (n = 26) and a control group with a normal CT finding (n = 26) were formed (mean ages 78.6 (SD 3.3) v 76.5 (SD 4.6) years; NS). RESULTS Dementia, vascular dementia, central brain atrophy on CT, disability in activities of daily living and instrumental ac...
متن کاملPolymersomes in polymersomes: multiple loading and permeability control.
Polymer vesicles polymersomes are vesicles obtained from the self-assembly of amphiphilic block copolymers in aqueous solution as a result of free-energy minimization. Their potential use as drug delivery systems, sensors, and/or nanoreactors has recently attracted a great deal of interest. Polymersomes exhibit larger mechanical stability and lower permeability than liposomes, their structural ...
متن کاملParamagnetic Porous Polymersomes
The ability of chelated Gd to serve as an effective magnetic resonance (MR) contrast agent largely depends on fast exchange rates between the Gd-bound water molecules and the surrounding bulk water. Because water diffuses slowly across lipid bilayers, liposomes with encapsulated chelated Gd have not been widely adopted as MR contrast agents. To overcome this limitation, we have synthesized chem...
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ژورنال
عنوان ژورنال: Faraday Discussions
سال: 2008
ISSN: 1359-6640,1364-5498
DOI: 10.1039/b717821b